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Polyneuritis equi

Polyneuritis equi is a rare, neurodegenerative disorder in horses that presents clinically with chronic relapsing signs. Because it is a complicated topic we combined our white papers into a book that explains the syndrome.

Click on the picture to the left and you can download the eBook Polyneuritis equi explained into your reader from Amazon. Or get a copy of the book by searching Siobhan Ellison in the Amazon books section. The book is $4.99 for Kindle and is occasionally free for downloading.

The purpose of our cumulative work is to raise awareness of polyneuritis equi (PNE) and develop a treatment for this unrelenting disease.  Because PNE is rare, it is overlooked as a diagnosis or confused with Equine Protozoal Myeloencephalitis (EPM).

A good clinical examination by a veterinarian can rule in PNE as the cause of disease.  A veterinarian will discern if the signs are related to spinal nerves or peripheral nerve (upper motor neuron or lower motor neuron) signs. There are six areas the veterinarian will evaluate that are muscle tone, sensitivity, paresis or paralysis, muscle atrophy or muscle fasciculations, and gait anomalies.

If PNE is on the differential diagnosis list the veterinarian may rule out some other diseases that look like PNE.  These diseases are EPM, trauma, rhinopneumonitis, rabies, and vitamin E deficiency.  A serum test that is negative for S. neurona will rule out EPM. A history and physical can rule out trauma.  If there is history of vaccination for EHV-1 and rabies, these diseases are probably not the issue.  And a horse on pasture probably doesn't have a vitamin E deficiency, but a serum sample can quickly rule that out.

Our polyneuritis equi project is designated under MUMS (minor use in a minor species) for the control of clinical signs associated with polyneuritis equi (PNE) in horses. We may be able provide treatment for your horse in a clinical trial.  There are some forms that need to be completed by the veterinarian and the horse owner. The horse has to have signs that FDA considers defining for PNE, complete the Fordyce exam form and we can assign a PNE score.

Please call us with any questions, we will be happy to discuss your case.  It is helpful if we know a little bit about the case so please fill out a some of the forms found on the tab: case analysis .

This trial is not placebo controlled.