For over 30 years the parasite S. neurona was placed at the center of EPM research. Despite overwhelming evidence, inflammation was ignored as a worthy target for treating clinical signs. As discussion about treating the signs of EPM grows, we propose a mechanism to explain why treatment can resolve clinical signs. It’s all based on data driven research, our work and work published by others. We offer a slide show that outlines our current thinking. We will give you references to the material in the presentation on request.